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KMID : 0378120030300010093
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Chungnam Medical Journal
2003 Volume.30 No. 1 p.93 ~ p.99
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The Risk Factors in the Treatment Failure Group and Recurrence Group of Kawasaki Disease
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Lee Hun-Young
Kim Jae-Chul
Lee Jae-Ho
Kil Hong-Ryang
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Abstract
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Several cases of Kawasaki disease(KD) were unresponsive to the initial treatment with intravenous immunoglobulin(IV1G). We retrospecitvely analyzed all children admitted with KD to determine the occurrence and variables associated with the initial IVIG treatment failure. All patients who were diagnosed for KD and atypical KD between January 1995 and December 2002 were enrolled. A total of 235patients were enrolled during the study period. All patients had been treated with IVIG and high dose ASA in acute phase. 196 patients had a normal baseline echocardiogram before treatment. 12 patients(6.1%) of them had developed the new coronary abnormalities after treatment. We divided the patients into two group : Treatment success group(n=184) vs. treatment failure group(n=12). Patients who were younger and had few numbers of symptom and longer duration of fever after treatment, a high CRP, a high Harada score were at risk of failure to respond to IVIG treatment. We found no correlation among gender, WBC count, hematocrit,albumin,erythrocyte sedimentation rate (ESR) with failure of the initial IVIG treatment. We found that treatment failure was more common in atypical KD and high Harada score group.
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KEYWORD
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Kawasaki disease, Immunoglobulin
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